We analyzed the mean number of cells in each layer (6 sections from each of the 6 control mice and 4 KO mice) the diameter of each cell counted (6 sections from each of the 4 control mice and 4 KO mice), and categorized cells as vertical and horizontal fusiform, pyriform, marginal (round), and multipolar cells according to the previous studies [ 56, 57].
The test group of 240 mice was categorized into 12 groups (20 mice each): Group I included normal control mice.
Of mice that were not conditioned (Experiment 1), 19% of A mice and 50% of BALB mice were categorized as unresponsive because they did not leave the peripheral compartment of the arena which was first entered within 20 min of the beginning of the testing session (see Materials and methods).
Mammary tumors in mice are categorized by using morphologic and architectural criteria.
LLA-TG-3 mice were categorized into three groups according to their tumor burden, that is, no tumor, low or high tumor burden.
Before conducting the study, mice were categorized into three groups (n = 10): (A) sham control (SC), (B) exposed (E1.6), and (C) exposed treated with 30 mg/kg of RG (G1.6).
For experiments in which all four strains were sampled (Experiments 1 3), approximately 9% of mice were categorized as 'unresponsive' during the place-preference tests because they exhibited very low levels of exploratory behavior.
LLA-TG-3 mice were categorized into three groups according to their tumor burden (no tumor: no visible lesions, age range: 4 8 weeks; low tumor burden: small tumors (2 3 per mouse; size range: approx. 60 100 mm), age range: 5 7 months; high tumor burden: large tumors (2 5 per mouse; size range: approx. 100 160 mm), age range: 7 10 months).
The dominant Gsdma3 alleles in mice are categorized as nonsense- and missense-mutations (Runkel et al. 2004; Lunny et al. 2005; Tanaka et al. 2007a; Sun et al. 2009; Li et al. 2010; Lei et al. 2011; Zhou et al. 2012).
Here, after a brief review of modelling human cancers in the mouse, we will discuss many of the prominent MB mouse models (categorized according to signaling pathway) published since 1997, when the first Ptc+/− mouse model was generated.
