Also, responses to OVA-loaded BM-DCs from TLR4-deficient mice, which cannot respond directly to MPL, could be enhanced by i.v. administration of MPL to levels similar to BM-DCs from TLR4-sufficient mice (Fig. 4D).
3 Conversely, db/ db mice that cannot respond to leptin show reduced BDNF expression in the hippocampus and hypothalamus.
For the HO-1−/− mouse that cannot respond to hypoxia by increasing CO production, it appears that neither reducing pulmonary vascular resistance (which occurs as a consequence of CO therapy) nor replacement of CO at the cardiomyocyte level is sufficient to prevent RV injury.
The PRLR knockout (KO) mouse [19], which cannot respond to either PL (in utero) or PRL (perinatal and postnatal periods), was used to assess the effects of lactogen resistance in vivo on BAT mass, mitochondrial structure, gene expression, and the adaptation to cold.
A similar switch is accompanied by the rapid generation of a strong Th2 response and enhanced immunity to the intestinal nematode Trichuris muris, in highly susceptible IL-10-deficient mice in which T cells cannot respond to IL-6 [ 57].
For instance, Dr. John Kopchick, a molecular endocrinologist at the Ohio University College of Osteopathic Medicine in Athens, created mice that produce growth hormone but cannot respond to it.
First, survey respondents who cannot respond for themselves were included in the analysis.
As mice lack the counterpart of human V γ9V δ2 T cells and thus cannot respond to IPP and NBPs, the mechanism of peritoneal inflammation in mice might be different from our human study.
"We cannot respond in a conventional manner.
It cannot respond to the opportunities which industry may offer".
