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However, loss of OHCs alone in ILDR1-deficient mice cannot explain the observed increase in ABR thresholds.
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Since the increase in Tregs is a general event in tumor-bearing mice which cannot explain the decreased proliferation capacity of lymphocytes from mice with high tumor burden, we hypothesized that immunosuppression could be correlated with the expression of IL-10 and TGF-β1.
While this reduction might explain a reduced impact of TNFR2 deficiency in obese mice, it cannot explain the observed reversal in the direction of the impact of TNFR2 deficiency on O3-induced AHR.
The reduced IGF-1 level suggests that GH is likely decreased in the older Ghsr-/ mice, but it cannot explain the lean phenotype.
However, these traits did not differ between our male and female db/db mice and, thus, cannot explain the differences observed in vascular senescence in these animals.
Grk4 is close to the Htt locus in mice but it is not contained within the YAC construct used to generate these mice [ 13]: thus this cannot explain the increased expression of this gene.
While reduced total IgG levels in the early life of β2m° mice can be explained by the absence of FcRn, the disease exacerbation in β2m° BWF1 mice cannot be explained by FcRn-deficiency.
The expression level of Neil1 was also similar in male and female R6/1 mice, and therefore the expression of Neil1 cannot explain the TNR expansion differences between genders.
Zipfel, personal communication), implying that any role of the HVR in S. pyogenes M5 infected mice cannot be explained through binding of FHL-1.
As the number of GNPs present in Mdm2puro/+ mice is equivalent to that in wild-type mice (Fig. 6B), the reduction in Shh target gene expression in these mice cannot be explained by an under-representation of GNPs.
Based on these results, the decreased fibrosis seen in or mice cannot be explained by lower levels of acute damage, as lung injury at 7 days after bleomycin instillation is even higher in mutant animals.
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