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In this study we showed that, in contrast to C57BL/6 Rag2−/−/γc−/− and NOD/Scid mice, newborn BALB/c Rag2−/−/γc−/− mice can support the development of human NK cells and CD56+ T cells after intrahepatic injection with hematopoietic stem cells.
The humanized mice can support persistent infection by HCV particles derived from either cell cultures or chronically infected patients.
Despite the aforementioned phenotype, KID and KIR female mice can support embryonic development and litter size is not affected.
Furthermore, the authors noted an increase in ductal branching at 4 and 16 weeks of age but not at 8 wks of age in HIT mice, whereas circulating IGF-I in KO-HIT mice can support mammary gland growth during this period without local IGF-I [ 16].
CD11c-DTR mice can support multiple DC depletions, up to six repeated injections of DT (4 ng/g) 3 days apart, without loss of weight and mortality observed in C57BL/6 transgenic mice (Zammit et al, 2005; and data not shown).
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For example, the first wave of parasites in a cow can peak with a total in excess of 10 trypanosomes, and therefore >10 will have switched to a different variant, while a mouse can support >10 parasites with >10 emerging variants.
It is known that human, rabbit and mouse antibodies can support the uptake of particles by mouse macrophages [35]; however, we tested species matched antibodies to confirm the effect of IgM on phagocytosis.
Here, the authors show that three-dimensional scaffolds generated from decellularized mouse thymus can support thymic epithelial cell survival in culture and maintain their unique molecular properties.
This indicates that the HIS mouse models can support a sustained HIV infection that is manageable with cART.
A striking conservation of the PDβ1 and PDβ2 (as well as PDβ3) regions among sheep, human and mouse [ 12] can support this observation, whereas the activity of the two similar PDβ3 and PDβ2 promoters could be correlated with their position from 5' to 3' within the locus.
Cervidized Prnp transgenic mouse brain homogenate can support CWD prion replication (32 ), and extensive in vitro conditioning of a CWD isolate by PMCA in a cervidized substrate (or passage in cervidized mice) was sufficient to overcome the barrier and enable efficient in vitro amplification in a humanized transgenic mouse substrate (33 ).
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studies can support
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Justyna Jupowicz-Kozak
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