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Previous study indicates that adding 1% of soluble fiber to the daily diet of mice can reduce blood lipid and liver TC and TG concentrations significantly.
Our studies found that daily oral intake of mushroom beta-glucan from Antrodia camphorata or Ganoderma lucidum in tumor-bearing mice can reduce the amount of M-CSF gene expression in the lungs and that daily oral intake of celecoxib in tumor-bearing mice can reduce the amount of M-CSF gene expression in the tumor tissues.
We preliminarily conclude that daily oral intake of mushroom beta-glucan from Antrodia camphorata and Ganoderma lucidum in tumor-bearing mice can reduce the amount of M-CSF gene expression in the lungs.
Daily oral intake of mushroom beta-glucan from Antrodia camphorata and Ganoderma lucidum in tumor-bearing mice can reduce the amount of M-CSF gene expression and in turn enhance differentiation of dendritic cells and their antigen presenting ability.
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Further, we showed that systemic PSI treatment fails to induce suppression of proteasome activity in the brain of wild-type mice but can reduce transiently up to 50%% the brain proteasome activity in transgenic PLP-hαSYN mice.
On the other hand, in lymphoma-bearing mice, lenalidomide can reduce MDSC numbers and reverts cancer-induced immunosuppression [ 105].
A number of studies have reported that (S -PA-824 iS -PA-824lerated in mice and can reduce M. tuberculoS -PA-824tisn levels after oral dosing (27, 28).
Other studies show that absence of functional p21 WAF1/CIP1) in the 129/Sv mouse strain can reduce progression to chronic renal failure [ 39] and that apolipoprotein E knockout mice do not have an increase in renal injury after subtotal nephrectomy in the presence of hyperlipidemia [ 40], suggesting a role for this protein in the development of secondary FSGS.
Recent data show that increasing GCase activity with adeno-associated viral vector (AAV) delivery of the enzyme into the brain of a GD mouse model can reduce the accumulation of SNCA, tau and ubiquitin (Sardi et al. 2013).
Expression of constitutively activated Akt1 in transgenic mice (myr-Akt1) can reduce apoptosis by 70% following targeted head and neck γ-radiation suggesting that apoptosis may have a larger role in γ-radiation-induced salivary gland dysfunction than originally reported [14].
Combined, these results demonstrate that in the adult mouse, androgen treatment can reduce bone resorption but has little overall anabolic activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com