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HIV-1 transgenic mice can potentially be used to study this and other post-gene expression steps.
Fos expression patterns observed in the brains of NR and R mice can potentially result from a combination of some or all of the following stimuli: sensitization to the challenge dose of cocaine, the effects of acute administration of the cocaine prime and/or the cocaine-associated context and subsequent reinstatement behaviour.
Furthermore, we identified that the expression of two groups of significantly altered transcription factors (TFs) Runx1, Mlxipl, Trim30 and Egr1, Tbx1, Nr1d1 in salivary gland tissue of melanoma-bearing mice can potentially be responsible for 82.6% of the up-regulated gene expression and 62.5% of the down-regulated gene expression, respectively, in the saliva of melanoma-bearing mice.
Furthermore, the results of such genetic studies in mice can potentially be leveraged toward development of novel prevention and treatment strategies.
As anti-Ad antibodies resulting from the initial immunization of the mice can potentially interfere with the efficacy of the rAd vector to function as a vaccine carrier during booster immunizations, we adopted a heterologous prime/boost strategy that entailed priming the animals with the rAd vector, followed by boosting with a plasmid vector encoding the same bivalent antigen gene.
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We measured serum osteoclast markers rather than urine markers because diabetes is associated with polyuria (which can confound measurements due to large differences in urine volume between control and diabetic mice) and can potentially result in nephropathy which could affect urine levels of measured factors.
QTL analysis using mouse models can potentially identify genes that are important for human diseases, which are often difficult to identify in human populations, due to the complexity of human genetic data.
Furthermore, mapping of CHO EST sequences to a mouse genomic scaffold can potentially reveal structural and regulatory features of the CHO genome [ 12].
By contrast, we have used eukaryotic ZFs to modulate the gene causing HD for up to four weeks in mouse brains 12, and can potentially make the entire protein sequence mouse-like, to avoid the immune system.
Mouse lemurs (genus Microcebus) can potentially be said to represent a cryptic species radiation.
The rapid evolution rates of mouse embryonic heart enhancers can potentially be explained by elevated rates of mutation and/or changes in the direction or intensity of natural selection.
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