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By separating the urine into different fractions, the scientists showed that a protein called darcin that they had identified in 2005 and which mice can only detect if their noses touch the urine is responsible for the frequent visits.
However, the delivery of the miRNA mimic into mice can only last a few days, limiting long-term efficacy.
Litter loss in laboratory mice can only be prevented efficiently when the problem is understood and the events leading up to pup death are known.
By contrast, homozygous Large myd mice can only be recognized by the smaller size at the age of 12 15 days, when they also present abnormal posturing of their hind limbs (Grewal et al., 2005).
This is because the mice can only learn that the dark compartment does not lead to shock only after they have experienced this event by re-entering the dark compartment.
It is now clear that human tumours are extremely heterogeneous even within an individual and these tumours occur in individuals with infinitely variable genotypes and extrapolating findings from the genetically engineered mice can only give a very limited picture of the complexity of the human disease.
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For translation, since the mouse can only control 2-DOF, UI widgets are used for controlling the Z axis and for constraining motion to a certain axis [11].
However, each mouse can only harbor two different copies of a mutant gene at one locus.
In the sample run, the mouse can only enter one of two goal arms to obtain a reward as the other arm is blocked.
With the caveat that results from SLC2A9-inactivation studies in the mouse can only be extrapolated to humans with much caution (given the presence of active urate oxidase (uricase) in mice but not humans), a recent study demonstrates that SLC2A9 is also an important basolateral uric acid efflux transporter into the gut enterocyte [ 20].
Excessive endothelium-restricted ET-1 expression in mice can not only cause endothelial dysfunction but also impair NOx-dependent vasorelaxation in resistance vessels and intensify vascular reactive oxygen species (ROS) production [44].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com