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Liu, Y., Lu, F., Kang, L., Wang, Z. & Wang, Y. Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium.
The results suggested that STB might protect against cognitive deficits and neurodegeneration induced by Aβ1 42 in mice by regulating the GLT-1 restoration as well as the capacity of GSK3β.
show that inactivation of the class II PI3K-C2β in mice, by regulating insulin receptor trafficking, enhances insulin sensitivity and protects against high-fat-diet-induced liver steatosis.
We found that berberine inhibited cell proliferation and induced apoptosis in tumor in Apcmin/+ mice by regulating signaling pathways involved in proliferation and apoptosis.
Our findings indicate that syndecan-4 is involved prominently in fibroblast-mediated cartilagedamage in hTNFtg mice by regulating the exression of disease-relevant MMPs.
XQLT alleviated allergic inflammation including AHR, IgE elevation and eosinophil infiltration in Der p stimulated mice by regulating neurotrophin and reducing TARC.
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Using miR-486 transgenic mice, Alexander and colleagues demonstrate that overexpression of miR-486 alleviates the dystrophic phenotype of mdx mice, likely by regulating dedicator of cytokinesis 3 (DOCK3), platelet-derived growth factor receptor β (PDGF- β), and the PTEN/AKT pathway, thus affecting the cell cycle and muscle regeneration in mdx muscle [ 97].
Taken together, our findings suggested that MTN may play a potential antidepressant-like role in the UCMS mouse model by regulating the NLRP3 inflammasome and mediating inflammatory cytokines and central neurotransmitters, which together provide insight towards the development of novel therapeutic treatments for depression.
Taken together, our results demonstrate that miR-29b plays a pivotal role in fetal mouse neurogenesis by regulating ICAT-mediated Wnt/ β-catenin signaling.
We conclude that ATRX is required for correct lamination of the mouse neocortex by regulating the timing of neuroprogenitor cell differentiation.
Data presented here shows that treatment with anti-IL-17A antibody significantly reduces metastasis to the bone and lungs in the two arthritic-BC mouse models by regulating the CXCR4/SDF-1 axis necessary for metastases.
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