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Arthritis was induced in thymectomized male DBA/1 mice by immunisation with bovine collagen type II.
We used a model of collagen-induced arthritis (CIA) in DBA/1 mice by immunisation (bovine type II collagen).
Their strategy was to induce mammary gland failure in mice by immunisation with an antibody specific to a milk protein that resulted in autoimmunity during lactation.
The disease is induced in genetically susceptible DBA/1 mice by immunisation with collagen type II (CII), and both T cell and B cell autoimmune responses are required for its development [ 17- 19].
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Chronic EAE induced in C57BL/6 mice by active immunisation with MOG35 55 peptide is currently the most widely used animal model in MS research.
The use of different HRP-conjugated Ig allowed us to determine the IgG, IgM, and total Ig levels induced in mouse sera by immunisation with anti-Id scFv and control immunogens.
For example, the downregulation of type 1 diabetes (T1D) in the non-obese diabetic (NOD) mouse by CFA immunisation has been shown to involve TNFα production and granzyme B/perforin-secreting Treg [ 42, 50].
The present study was performed with hyperimmune serum obtained by mice immunisation with heat-inactivated whole cell S. pneumoniae.
These mouse monoclonal anti-Amb a 1 antibodies (clone E10) were obtained by immunisation of mice with the purified recombinant Amb a 1 protein (rAmb a 1), as described by Wopfner et al.
They mention the high immunogenicity of the Cry1Ac protoxin demonstrated by its capacity to induce significant specific antibody responses in serum and mucosal-secretions recovered from the small and large intestine, bronchoalveolar and vaginal lavages of mice after immunisation by every tested route, such as intraperitoneal, intragastric, intranasal, rectal [36, 54] and vaginal [55].
Monoclonal antibody (McAb) Po66 has been obtained by immunisation of mice against a human lung squamous cell carcinoma.
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