Modulation of distinct asthmatic phenotypes in mice by dose-dependent inhalation of microbial products.
Since we previously demonstrated that serum IL-7 levels are higher in NSCLC patients with bone metastases than in patients without bone lesions, we tested the IL-7 production in the two groups of mice, by dosing serum IL-7.
This effect was further confirmed by significant inhibition of castor oil induced diarrhea in mice by various doses of LCME.
We observed apparent cure of tumors in three out of five mice by both doses of the conjugate without recurrence longer than 120 days after tumor inoculation (Fig. 6c).
Tumours were induced s.c. in C3H/uip, SJL/uip, DBA/2 uip, C57BL/6 uip and BDF1 mice by different doses of methylcholanthrene (MCA) diluted in oil: 1 mg, 0.1 mg and 0.01 mg.
Our results showed that PSA-I-3 could increase the survival of mice by lethal-dose LPS and heat-killed E. coli in vivo and inhibit significantly the TNFα release from LPS-stimulated RAW264.7 cells in vitro.
Additional experiments demonstrated that the modification of sEPSCs frequency in master mice by low doses of cocaine (0.1, 1.0 μM) was abolished in the presence of TTX (F3, 5=7.326, P=0.0030; post- hoc test, P<0.05, cocaine at 10 versus 0, 0.1, 1 μM, Figure 4D).
Acute liver failure was induced in BALB/c mice by a toxic dose of acetaminophen (APAP).
ALI was induced in C57BL/6 male mice by a single dose of APAP (350 mg/kg) by intraperitoneal injection.
Therefore, we assessed the effect of sustained PAF activity on mortality in LPS-induced endotoxemicemice by administering identical doses of cPAF (1 µg/mouse) or PAF (1 µg/mouse) immediately after LPS challenge.
Induction of thymic lymphomas was triggered in 4-week-old mice by repeated low-dose irradiation (1.75 Gy).
