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In this study, we have analyzed the antigen specific immune responses triggered in mice by different combinations of vaccine vehicles expressing the multiepitope polypeptide TAB13.

Compared with the model group, groups treated with the metformin and with different proportions of astragaloside and curcumin help lower the blood glucose levels and GSP levels, increase glycogen stores of model mice by different degrees, and avoid pathological changes of pancreas in the model mice.

Whether a similar dose-response relationship would be observed following immunization of mice by different anatomical routes, or in other species, is under investigation.

Genetic studies in mice by different groups have confirmed that UBE2N is critical for NF- κB and MAPKs activation in most immune cells.

Tumours were induced s.c. in C3H/uip, SJL/uip, DBA/2 uip, C57BL/6 uip and BDF1 mice by different doses of methylcholanthrene (MCA) diluted in oil: 1 mg, 0.1 mg and 0.01 mg.

Subsequent generation of PARP-1 null mice by different groups targeting other exons (de Murcia et al. exon 4 in a 129/Sv, C57BL/6 mixed background; Masutani et al. exon 1 in an ICR, 129/Sv mixed background) also confirmed the absence of an obviously abnormal phenotype of Parp1 knockout mice.

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The rAAV-GFP was administered to the ICR mouse by different routes and the green fluorescence that was expressed in different organs was analyzed at 3 weeks after administration.

However, the lethality percentage of nontransgenic FVB/n mice and of hK18 WT mice caused by different forms of stress, i.e. administration of Fas antibody alone, streptozotosin or Fas antibody combined with PUGNAc (an inhibitor of N-acetyl-D-glucosaminidase) (Ku et al., 2010), was similar (Table 1).

Left half shows the six QTLs in mice, coloured by different studies and the confidence intervals are marked on the mouse chromosome.

ATF2 mutant mice generated by different gene targeting approaches have demonstrated the importance of ATF2 for tissue development and integrity and for postnatal viability.

Several groups, including ours, have tried to answer this question using Tet2-mutant mice generated by different strategies.

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