Our results suggest that modification of Au DENPs with PEG molecules can prolong their blood circulation time in the ApoE-/ mice by decreasing the rapid uptake and clearance in the RES. Figure 6 Representative in vivo micro-CT images of macrophages in ApoE -/- mice model of atherosclerosis.
Ablation of iNOS improved the energy balance of ob/ob mice by decreasing food efficiency through an increase in thermogenesis.
Taken together, ablation of iNOS improves the energy balance of ob/ob mice by decreasing energy intake (reduced food intake), and by increasing energy expenditure (increased rectal temperature).
Hence, mechanistically, early parity decreases the hormone responsiveness of the mammary gland in mice by decreasing the number of estrogen/progesterone receptor-positive luminal cells.
As discussed above, a receptor-II trap ligand inhibits Smad2/3 by targeting gdf11 and improves anemia in thalassemic mice by decreasing stress erythropoiesis.
Low doses of THC reduced atherosclerotic lesion size in apolipoprotein E (ApoE)−/− mice by decreasing macrophage migratory capacity, which resulted in reduced lesional macrophage content [ 15].
More recently, Moura et al. [ 14] demonstrated that E. oleracea extract reduces acute lung inflammation in mice, by decreasing the numbers of alveolar macrophages and neutrophils in lung sections and decreasing TNF-α expression in lung homogenates.
For example, MONCPT, a topoisomerase I inhibitor, decreases B16F10 melanoma metastases in C57BL/6 mice by decreasing ERK (extracellular regulated kinase) phosphorylation, HIF-1α expression and the secretion of VEGF and metalloproteinase 9.
Methionine restriction was able to significantly reverse this effect in the 12-month-old mice by decreasing body weight by 7.8 g by week 5 of dietary treatment (Fig. 1A).
Notably, one recent study by Liang and colleagues revealed that latexin functions in the negative control of the hematopoietic stem cell (HSC) populations in mice by decreasing cell replication and increasing apoptosis [ 9].
