The R133C mutation has not previously been modelled in mice, but it has been proposed that its milder phenotype is due to retention of binding to 5-methylcytosine accompanied by loss of binding to hydroxymethylcytosine (hmC) (15).
After intraperitoneal injection, 4-iodopropofol did not produce anesthesia in mice, but it was not detected in serum or brain.
The study was performed on brain tissue from mice, but it is likely to apply to people as well, Barres said.
People and other higher primates may have the same basic circuitry as mice, but it is probably overlain by many more controls.
Introduction: The free exploratory paradigm is regarded as a reliable test for trait anxiety in mice but it may also be useful in rats.
Ethanol exposure significantly induced hepatic injury in the livers of ethanol-fed mice, but it was alleviated in ethanol with AXT-fed mice.
The number of neutrophils in blood was elevated in ethanol-fed mice, but it was decreased in ethanol with AXT-fed mice.
In recent months, researchers have discovered that a prion from hamsters, thought never to infect mice, not only replicates profusely in mice but it does so without producing disease symptoms.
So far, the technique has been tested only in mice, but it has managed to grow hairs on human skin grafted onto the animals.
Rate of bodyweight-gain was lower in ethanol-fed mice than in pair-fed mice, but it was higher in ethanol-fed mice than ethanol with AXT-fed mice.
"They're not going to replace mice, but it gives another tool to scientists".
