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Wild mice breeding freely in semi-natural enclosures showed inbreeding avoidance.
We thank R. Natsume for chimeric mouse preparation, Drs. T. Yamamoto and T. Tezuka for PTPMEG antibody, and T. Nagamoto, Y. Nakano, and T. Tsunoda for help in mice breeding.
FH performed the nude mice breeding and the main experiments.
IN, AV and WO contributed to mice breeding, treatments and biochemical analysis.
All mice breeding and manipulations were performed in accordance with the Canadian Council on Animal Research.
IN, AV and WO contributed to the mice breeding, treatments and preconditioning.
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Mice were obtained from the Institute of Chemistry mouse breeding facility, and used following the authorization of the Institutional Committee for Research and Animal Studies.
It is a long and cumbersome procedure that involves combining pieces of DNA in embryonic stem cells and mouse breeding.
Then they checked the computer-predicted loci against published QTLs mapped through the conventional process of mouse breeding.
The authors are grateful to Minoru Tanaka and Sachiko Hirokawa for mouse breeding.
Mouse breeding and experimental protocols were subject to Institutional ethical approval and were performed under the terms of a U.K. Government Home Office licence.
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