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Their closest living relatives are kangaroo mice and pocket mice, both of which are also heteromyids.
To specifically implicate IRF8 and cDC1s in this decreased CD8+ T-cell response, we employed IRF8−/− and Batf3−/− mice, both of which have impaired cDC1 differentiation18,19,42.
We injected LacZ-IRES-Cre plasmid into Mst1flox/flox Mst2flox/flox mice and Mob1aflox/flox Mob1btr/tr mice, both of which lack Hippo signalling17,18,21.
In cGVHD model mice, both of continuous and discontinuous treatment with SAT05f was effective on reducing anti-ssDNA antibody production, decreasing renal IgG deposition and delaying the onset of lupus nephritis.
In the next experiment, the authors set out to better understand the exact role of the iNKT cells by examining two strains of mice, both of which are deficient in iNKT cells, and a group of control mice, all on a high-fat diet.
To confirm their hunch, the researchers attempted to induce tolerance in two strains of transgenic mice, both of which have mutations that prevent T cell apoptosis, or programmed cell death.
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Blood from Vav1-P1cKO micexhibiteded both of these characteristics, demonstrating that Piezo1-deficient RBCs are overhydrated.
Mechanical ventilation with high VT induced an inflammatory response in the lungs of mice of both genotypes, but more severe in WT than in Tpl2-/-mice.
Groups consisting of 5 to 6 mice of both genders, at the age of 12 to 13 weeks, were investigated under resting and different catabolic conditions.
To ride with him to the meeting, I had to wedge into the back seat of his car between two mouse cages, both of which were, thankfully, empty.
Wnt3a increased H2O2 levels in endothelial cells and impaired endothelium-dependent vasorelaxation in mouse aortas, both of which were rescued by p66(Shc) knockdown.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com