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As summarized in Fig.  2, we found that the body weight of Dnmt1+/+ mice was significantly higher than that of Dnmt1+/− mice both for the female group (p = 0.0012) and the male group (p = 0.0069).

At two samplings, the dosage-dependent decrease in the WBC count was significantly lower for mice in one or both of the two highest dosages groups compared to control mice; both for the 400 and 600 kBq/kg 227Th-trastuzumab groups at 3 weeks after injection, and for the 600 kBq/kg227Th-trastuzumab at 6-week time points.

We observed that cells at the margins represented, in WT and STOP null mice, 71% ±10and 63%±8 of the whole proliferating cells, respectively; there was a statistically significant increase in proliferating cells in STOP null mice as compared to WT mice, both for marginal and central localisations (p<0.05).

As expected, we noted increased numbers of CLS and levels of CD45+ cells in lard-fed versus fish-oil-fed mice, both for CONV-R and GF mice.

Tumours of Apc YE mice were on average smaller compared with tumours from Apc mice, both for males (p=0.0001) and females (p=0.022) (figure 5D and supplementary figure S3A, available online only).

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As Tek+/CreCD146floxed/floxe mice (CD146EC-KO mice) were viable, these mice were further bred to Tek+/+CD146floxed/floxed mice (WT mice), resulting in 50%% CD146EC-KO mice and 50 % WT mice, both of which were used for subsequent investigations (Fig. 1B).

Double heterozygous F1 males and females were mated to generate Bax+/−/Rpe65−/− F2 mice both heterozygous for Bax and homozygous for Rpe65.

MRL mice and BXSB mice, both mouse models for lupus-like disease, have previously been described to have lower C4 levels than B6 mice [ 45].

Humans and mice both possess two receptors for TNFα, TNFR1A (p55) and TNFR1B (p75) [ 25].

This makes the mouse vital, both for finding genes among the landscape of junk contained in the genome and for understanding exactly what these genes can do.

Mice are always bred heterozygous for the targeted alleles to generate mice for both controls and experimental group.

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