In the tissue distribution studies, the AUC could not be determined in individual mice because of the destructive study design.
However, he cautions that gossypol-free seeds might be more vulnerable to mice because of their reduced toxicity.
However, drusen are rarely seen in mice because of their simpler Bruch's membrane and different process of lipofuscin extrusion compared with humans.
The experimental investigation of nerve regeneration after microsurgical repair is usually carried out in rats, rather than mice, because of the larger sized peripheral nerves.
That role would make sense, as wetas are known as "invertebrate mice" because of their size and nocturnal habitats, Burns points out.
In most cases, stem cell studies involving animal models use mice because of their ease in handling, reproduction, and genetic manipulation, making them appropriate for proof-of-principle studies.
Since arterial blood sampling, the gold standard to obtain arterial input curves is very difficult in mice because of the small size and fragility of the mouse blood arteries; an alternative method to acquire the arterial plasma input curve for the kinetic model is proposed.
Using a skin transplantation model, we observed that simultaneous administration of monoclonal antibodies (mAb) targeting CD45RB and CD40L prolonged skin allograft in co-stimulation blockade (CTLA4-Ig and anti-CD40L mAb)–resistant mice, because of reducing CD8+ T cells and CD4+ CD45RBhigh T cells.
The most common subjects are mice, because of the availability of technical tools.
A more likely explanation, however, is that less PrPSc and infectivity accumulate in Tga20 mice because of their shortened survival time.
The evidence that DDSBs are not efficiently detected in older mice because of a lower activity of the ATM kinase supports this idea [29].
