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One future refinement would be to purify cells from mice bearing multiple fluorescent knock-ins of different colors (e.g. SSTF1GFP|SSTF2 dsRed).
In our efforts of analyzing the impact of tumor growth on NK cell development, we observed a major reduction of NK cell numbers in mice bearing multiple lineages of tumor cells.
However, mice bearing multiple lung tumours were less able to cope with the combined treatment than those bearing s.c. tumours.
To assess the therapeutic efficacy of JQ1 in vivo, mice bearing multiple myeloma (MM) lesions were treated with JQ1 before evaluation for tumor burden and overall survival.
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In a xenograft mouse model, i.v. administration of tyropeptin-boronic acid derivatives inhibits proteasome in tumors and clearly suppresses tumor growth in mice bearing human multiple myeloma.
This physical-chemical phenotype, unique among the mouse IgG subclasses, has been rationalized [ 25] with reference to the remarkable association between IgG3 production and immunization with polysaccharide (or, less commonly, protein) antigens bearing multiple copies of the same epitope [ 26].
Intravenous injection of one such agent, JS-K, into mice bearing subcutaneously implanted multiple myeloma tumors on the flank, resulted in an impressive inhibition of tumor growth and induction of extensive apoptosis throughout the tumor.
Figure 2 Co-registration of fDOT and micro-PET in a mouse bearing a multiple endocrine neoplasis syndrome type 2A tumor xenograft.
In these studies in which mice were imaged in groups of three or four after injection of F-FDG, F-FLT or Ga-EDTA, it was shown that PSF PET/CT can provide good quality images and accurate quantification of the radioactivity within the imaged lesions of mice bearing tumours and has the capacity to simultaneously image multiple mice in static or dynamic mode.
Multiple studies were performed using HB22.7 to treat nude mice bearing Raji xenografts.
Moreover, nude mice bearing subcutaneously (s.c).
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