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Thrombocytopenia present from weeks 1 10 (Tables 1, 2) was most severe in highly infected mice at three weeks post-infection.
ABR measurements of these mice at three weeks of age revealed no differences (Fig. 3C), suggesting that compensatory mechanisms most likely do not explain the lack of a TRPML3 hearing phenotype.
To verify findings, serum ferritin was measured in duplicated infection experiments using an additional 10 S. Typhimurium-infected and three mock-infected control mice at three weeks post-infection.
Hepatic microthrombi were present in two of six mice at one and six weeks post-infection, while marked thrombosis was present in the spleen (Figure 3B) and liver (not shown) in two of six mice at three weeks post-infection.
To determine how loss of both γcyto-actin and dystrophin affected muscle performance in vivo, whole body tension analysis was conducted on mice at three months and twelve months of age.
While the number of motor neurons was normal in Cra1/+ mice at three months of age, a severe reduction in motor neuron number was reported at 16 months of age in Cra1/+ mice and 18 months of age in Loa/+ mice, consistent with the progressive symptoms.
Similar(27)
They have done this with mice before birth and with mice at four weeks of age.
The formulation was orally administered to mice at two dose levels (D1 and D2).
Recently, layered double hydroxide of magnesium-aluminium was administered to male Balb/c mice at four different doses [32].
Histopathological observations of lungs from all mice at two weeks post challenge revealed healthy lung parenchyma.
Like µMT and JHD mice, the granuloma pathology of OBF-1-null mice was comparable to that of littermate control mice at eight weeks post-infection [8] [11].
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