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Open field testing was performed on naive male mice at one (n = 13, wild type; n = 9, Mcoln1 −/− ) and two (n = 17, wild type; n = 18, Mcoln1 −/− ) months of age under regular light conditions.
A footprint test was performed by painting hindlimbs with non-toxic ink and placing mice at one end of an enclosed, dark tunnel on white paper.
We found that reductions in serum IGF-1 levels in iLID mice at one year resulted in significant loss of cortical bone at two years.
Liver tissues from wildtype and mutant mice at one year of age were collected for mRNA extraction and gene expression analyses.
When transplanted with the same number of myoblasts (5 × 10) into the TA muscles, the fluorescence intensity of the TA muscles in C57BL/6 mice was significantly higher than that in the BALB/c and mdx mice, and slightly lower than that in the nude mice at one, two and three months after transplantation.
To investigate if the identified body weight differences detected at birth would persist in postnatal life we next analysed wild type, Grb10 m/+, Dlk1 +/p and Grb10 m/+ /Dlk1 +/p mice at one week, three to six months and more than six to nine months of age.
Similar(47)
When they analyzed the toxic compounds in the frogs' skin, they found that four-fifths of the PTX had been converted to a much more potent form that caused convulsions and death in mice at one-fifth the dose of the original.
Interestingly, detailed observations of the myofiber histology indicated more nuclei were localized in the central and basal lamina of the myofibers of the transgenic mice although these mice were at one year of age.
The present study offers little insight into the time course of diabetes-related SAN dysfunction as we evaluated mice only at one time point.
Chronic administration of 17beta-oestradiol (via drinking water) or the oral contraceptive Enovid (norethynodrel and mestranol) (0-1 mg injected s.c. twice weekly) to nulliparous C3H/HeJ female mice, beginning at one month of age and terminating at 20 months (17beta-oestradiol) or 22 months (Enovid), significantly increased the incidence of mammary tumours over solvent-treated controls.
We found an initial significant decrease of neutrophils in wounded skin of CD177−/− mice at day one after administration of Staphylococcus aureus (Fig. 4A).
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