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The trick, the researchers wrote, was to inoculate the brown mice at birth, or even in utero, with cells from the white mice.
Body size, skeletal structure and trabecular bone were similar in Zdhhc13 WT and mutant mice at birth.
These studies provided us with a previously uncharacterized expressed sequence tag (EST) that was markedly induced in hearts of VLCAD-deficient mice at birth.
The lack of difference in PP number between WT and KO mice at birth indicates that Card15/Nod2 plays its role during post natal development of the GALT.
We noted no differences in the anatomy of the external or internal reproductive organs of Magel2-null mice at birth, and in particular did not detect any male mice with cryptorchidism.
As expected, bilateral renal agenesis was observed in about 90% of all Grem1-deficient mice at birth in the presence of either one or two functional Bmp7 alleles (Table 1) [17] [17].
Similar(33)
Tamoxifen (Sigma) was administered to the αMHC-MerCreMer; STAT3fl/fl mice (STAT3−/− mice) and STAT3fl/fl; STAT3fl/fl mice (STAT3+/+mice) at birth (postnatal day 0), according to a protocol published previously.
Dbx1-derived interneurons (hereafter Dbx1 neurons) in perinatal mice are inspiratory modulated, and Dbx1-null mice die at birth without ever breathing (Bouvier et al., 2010; Gray et al., 2010; Picardo et al., 2013).
These mice die at birth; however, hippocampal neurons cultured from embryonic mice form synapses and manifest a virtual absence of evoked neurotransmission and highly diminished rate of spontaneous neurotransmitter release (Bronk et al., 2007).
T-cre; Fgfr1 mice die at birth and show reduced limb skeleton, misshapen forelimb/hindlimb bud and missing digits, whereas Shh-cre Fgfr1 mice display normal limb bud size, but missed a digit.
Col25a1 knock out mice die at birth due to respiratory defects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com