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Decreased expression levels of adipogenic transcription factors and lipogenic enzymes suggested impairment of adipogenesis in HSL null mice, as also demonstrated in mice lacking both HSL and leptin [19].

This staining supported the disrupted formation of the granular layer in the mature anterior cerebellum of Txnrd1-NS null mice as also revealed by the H&E staining (Fig. 3).

Nonetheless, oocytes from young ICR mice (as also happens in the other mouse strains except AKR/J) are able to repair the initial DNA damage during a 6 h incubation period, but, oocytes from aged mice are not.

Evidently, ouabain effects on systemic blood pressure are peculiar to rats but not mice as also noted before by others [ 21].

Hypoxic/hypercapnic conditions known to be lethal to other mammals had no visible effect on these Indian pygmy field mice as also reported in case of subterranean mole rats.

When the MLNC CD4+ T-cell compartment was analyzed for expression of the Treg-cell marker Foxp3, similar proportions were found in naïve BALB/c and IL-6-deficient mice, as also noted in mice impaired in gp130 signaling [ 29] (Fig. 4A); in both genotypes, H. polygyrus infection stimulates a small but significant increment in the percentage of Foxp3+ T cells.

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Hair graying is not related to normal aging in the mouse, as also demonstrated by our own observation that Control littermate mice remained uniformly black well after 2 years of age.

As expected, ApoE−/− mice had higher plasma triglycerides, total cholesterol and LDL-cholesterol than wt mice and as also described by others[33], [34], all three parameters were further increased in diabetic ApoE−/− mice.

Although we focused our experiments on hepatocytes, it is likely that the adipose tissue and muscle are also functionally involved in the global metabolic improvement seen in PI3K-C2β KI mice, as we also observed clearly enhanced insulin-induced Akt activation in these tissues.

Interestingly, the two cell lines from carcinoma ex pleomorphic adenoma [ 13, 22] were demonstrated to have characteristics of squamous cell carcinoma when they were transplanted into nude mice, as was also observed in the present study.

HFD-D mice were characterised by higher glycaemia at all time points compared with HFD-DR mice (figure 1B), as also shown by the glycaemic index (figure 1C).

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