Furthermore, young adult Hmox1 mice were vulnerable to mortality and hepatic necrosis when challenged with endotoxin.
Remarkably, however, male tfm mice were vulnerable to Lef1 haploinsufficiency, similar to females (Figure 5).
Dysmyelinated axons in shiverer mice are highly vulnerable to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated toxicity.
Dysmyelinated axons in shiverer mice are highly vulnerable to A-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated toxicity.
This damage is produced not only in obvious ways (a spilled cup of coffee), but also in subtle ways (even the cumulative effect of sticky fingers or crumbs can ruin equipment -- keyboards have been damaged at the rate of one per day from food crumbs alone, and mice are equally vulnerable).
Also the fact that the increased expression of thermogenic and browning genes in Bmp8b TG mice occurred early in the post-weaning phase, when mice are more vulnerable to low temperatures, suggested the physiological relevance of BMP8b mediating the adaptation to cold demands.
These autophagy-deficient PEPCK-Atg7−/− mice are particularly vulnerable to cisplatin- and ischemia-reperfusion induced acute renal injury, suggesting potent renal protection by ATG7-mediated autophagy (Jiang et al., 2012).
Moreover, Als2-null mice are slightly vulnerable to oxidative stress [28].
We previously showed that cyclooxygenase-2 deficient (COX-2−/−) mice are more vulnerable to KA-induced excitotoxicity.
These results suggest that independent of abnormal blood flow response, myofibers in mdx mice are already vulnerable to mechanical stress.
