The present study indicates that the hepatitis of mice is triggered by nano-anatase TiO2 activation of inflammatory cytokines that resulted in disruption of liver tissue, and hepatocyte injury and apoptosis.
In summary, this is the first report showing that phototransduction-dependent apoptosis of rod photoreceptors in Rpe65−/− mice is triggered by the Bcl-2-related apoptotic pathway.
Thus, the psoriasis-like skin disease in PPARβ/δ transgenic mice is triggered solely by activation of PPARβ/δ overexpressed in the skin, but not by endogenous murine PPARβ/δ.
Here we show that the skin inflammation in Sharpin cpdm/cpdm mice is triggered by TNFR1-mediated TRADD- and FADD-dependent apoptosis of keratinocytes.
Asymmetric knee arthritis in TNF-Tg mice is triggered by simultaneous collapse of ipsilateral PLN and ILN, which is likely due to B-in translocation to the lumen of lymphatic vessels of both lymph nodes and result in a dramatic decrease in afferent lymphatic flow in the lower limb.
Land mines are triggered.
Thus, once the stimulatory signals are triggered, JTX-treated mice produce altered levels of IFN-α protein.
Furthermore, the thrombotic effect observed in FcγRIIa transgenic mice could be triggered by IC comprising soluble mouse CD40L and the anti-mouse CD40L antibody MR1 carrying a human Fc region (hMR1), but not by IC of soluble mouse CD40L and aglycosyl hMR1.
Intriguingly, despite similar overall lung bacterial burdens early during infection, we detected a unique Mtb compartmentalization in airway myeloid cells in TB susceptible mice, which was triggered by augmented Mtb replication concurrent with cell death of AMs.
Given the multi-nuclear nature of skeletal muscle fibers, these focal disruptions of the IF cytoskeleton in heterozygous man and mice may preferentially be triggered in areas with higher levels of mutant desmin protein.
