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Some of these compounds may play a role in regulating our stress levels and even temperament: when gut microbes from easygoing, adventurous mice are transplanted into the guts of anxious and timid mice, they become more adventurous.

In addition, we utilized the chimeric severe combined immunodeficient mouse/human (SCID-hu) system in which mice are transplanted with human fetal thymus and liver under the renal capsule, forming a conjoint human organ that phenotypically and functionally recapitulates human thymopoiesis within the mouse [17], [18].

Usually, immunodeficient mice are transplanted with primary human cells to develop a "human" immune system.

Furthermore, when the gut microbes from normal mice are transplanted into germ-free recipients, there is an increase in weight and adiposity without any added food consumption.

Further studies in which normal mammary tissue pieces from p190B+/-Neu mice are transplanted into wild-type stroma and are allowed to proceed through the stochastic process of tumor formation will be required to examine preneoplastic lesions in more detail.

When SSCs from young, fertile male mice are transplanted into 1-and 2-year-old atrophied testis, only 1-year-old testis showed regeneration, thus indicating age-related alterations in somatic cells can impair spermatogenesis.

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To evaluate whether cells from the primary recipients had the capacity to engraft and initiate myeloid disease upon serial transplantations, BM cells from primary mice were transplanted, either unsorted or sorted for GFP expression, into sublethally irradiated NSG mice.

In order to definitively determine the mammary gland of origin and therefore a successful versus unsuccessful mammary gland transplantation, mammary glands from GFP expressing mice were transplanted into non-GFP expressing hosts.

In all cases, bone marrow from female mice was transplanted into male mice and the effectiveness of the transplantation was controlled by FISH.

When bone marrow from these chimeric mice was transplanted into secondary recipients, mixed chimerism was >80% three months post-transplantation, suggesting that the HPCs had acquired self-renewal characteristics [17] and behaved similar to bone marrow cells (manuscript in preparation).

In our previous transplantation studies in which cells from 10-week-old virgin FVB mice were transplanted but the animals were not mated prior to whole mounting, no alveolar-only type outgrowths were observed [ 11, 26].

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