Suggestions(5)
Exact(6)
However, it is unclear whether the levels in lupus patients, which are considerably less than seen in BAFF transgenic mice, are sufficient to produce these abnormalities.
The findings suggest that the modest BAFF elevations in NZB mice are sufficient to perturb B cell tolerance, particularly when acting in concert with B cell functional abnormalities and T cell help.
Therefore, we hypothesized that the minimal levels of intact α-DG species observed in Hp/− mice are sufficient to maintain linkage to laminin and prevent disease progression.
However, even low levels of Cx40 expression, like in Cx40+/− mice, are sufficient to maintain Cx37 expression at a level comparable to WT aortic endothelium.
Collectively, these data demonstrate that the CD4+ T cells from B6.SLE mice are sufficient to accelerate atherosclerosis when transferred to a non-lupus, atherosclerosis-susceptible mouse.
To determine whether the deacetylation of histones and the increase in HDACs in fibroblasts from bleomycin-injured mice are sufficient to cause diminished expression of Fas, we treated cells with two nonselective HDAC inhibitors, trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA).
Similar(54)
Furthermore, restoration of Crim1 levels in just the lens tissue of Crim1KST264 mice is sufficient to ameliorate most of the dysgenesis observed in the mutant animals.
Two RTB-specific neutralizing monoclonal IgG1 antibodies, 24B11 and SylH3, when passively administered to mice, were sufficient to protect the animals against a 5×LD50 dose of ricin.
Furthermore, restoring CFTR expression in the airway epithelium of CF mice is sufficient to restore normal bacterial clearance therein, which suggests a minimal role for CFTR expression in non-epithelial cells, at least in this model [92].
Specifically, disruption of Mbnl1 in mice is sufficient to recapitulate key features of the disease [32].
Interestingly, systemic infusion of absorbed amounts of LPS in mice was sufficient for diet-induced obesity and metabolic syndrome, even when the mice were fed standard diets [32].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com