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These findings show that, contrary to our initial hypothesis, aged MCK-UCP1 mice are still able to efficiently respond to NMJ-inducing stimulatory nerve factors and suggest that the NMJ defects of these mice are rather presynaptic.
Such models, especially models using immune-competent mice, are rather scarce.
Furthermore, genetically modified mice are rather costly and may impose a substantial financial constraint to a research as well as limit the number of samples.
Interestingly, a striking difference between GHR deficient or GH disrupted mice and hNAG-1 mice is that GHR deficient mice are rather obese which have increased subcutaneous adiposity while hNAG-1 mice have decreased adiposity [ 1].
During the study period, we did not observe any adverse effects in mice at the higher dose, suggesting that pharmacokinetics and drug drug interactions in mice are rather poor predictors of events in humans.
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Hq mice were rather hypoglycemic compared to wt.
Except for the gene expression changes (Fig. 5 and Fig. 6), the degree to which the circadian rhythm is disrupted in these AMPK-deficient mice is rather modest.
The increase in adiponectin levels in Nscl-2 mice was rather unexpected since adiponectin levels are usually inversely correlated to percent body fat resulting in the reduction of adiponectin concentrations in obese animals (see [36] for a review).
Collectively, these data show that the impaired thymic generation of Treg cells in IκBα-SR Tg mice is rather due to a Treg cell-intrinsic defect than an extrinsic one, because it cannot be compensated despite the presence of wild-type derived T lymphocytes and soluble factors.
However, the regulation of PI3K activation in p85 α-deficient mice is rather complex.
However, the effect of royal jelly on the maximal lifespan of mice was rather disappointing [ 35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com