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Strategies for gene targeting, ES cell screening and genotyping of ΔT mice are provided in Fig. S1.
NF-L null mice are provided by Dr. Jean-Pierre Julien, Laval University, Canada [20]; Myo Va mutants (DL20J breeders [21]) were fed with high fat (9%) diet (Purina, St . Louis MO), and are a kind gift of Dr. Nancy A. Jenkins (NCI, MD).
Case studies of vitamin A-deficient (VAD) mice and Stra8-deficient mice are provided below.
Stacy2005 A set of further control recordings in wild-type mice are provided [ 17].
Video recordings of representative seizures in D/+ and D/D mice are provided as Supplementary Material.
Data on the generation of these mutant mice are provided in Fig 4A.
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These new genetically engineered mice are providing a window into what happens during a heart beat and also illuminating the electrical signals that coordinate the beating.
Ninj1 KO mice were provided by GT Oh20,42.
Heterozygous SCOP/PHLPP1 wt and KO mice were provided as a generous gift from Dr. Tianyan Gao at University of Kentucky.
C3H/HeJ (C3H-2Kk/I-Ak-Ak) mice were provided by Dr. Niels Câmara (University of São Paulo, São Paulo, Brazil) or purchased from The Jackson Laboratory.
Il10−/− (H-2Kb/I-Ab) mice were provided by Dr. Ana M. C. Faria (Federal University of Minas Gerais, Belo Horizonte, Brazil).
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