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The IL-6KO mice are only commercially available on the C57BL/6 background which is genetically resistant to CB3-induced chronic autoimmune myocarditis, therefore, co-treatment with LPS at the time of infection is required to overcome genetic resistance [17].

We examined several immunodeficient mouse models and found, as previously reported, that while engraftment in NOD/Scid mice is not dependent on age at the time of stem cell delivery, Rag2−/−/γc−/− mice are only able to support high levels of engraftment when stem cells are delivered at birth [9], [31].

But one must stress that these mice are only partially humanized.

Primary hepatocyte spheroids from species frequently used in safety assessment, such as monkey, dog and mice, are only poorly characterized.

The mammary glands of nude mice are only one-third the size of a normal gland during pregnancy, and nude mice are unable to lactate.

Severe hyperglycemia and hyperinsulinemia in C57BL/6J mice are only known to develop after 24 weeks of feeding with high-fat diet [ 19].

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Despite high RTB-specific serum antibody titers, groups of RTB immunized mice were only partially immune to ricin challenge.

According to this scenario, the 'CB3' receptor is only partially responsible for newborn milk suckling since the cannabinoid CB1 knockout mice were only partially affected by the antagonist.

Interestingly, the Cox1 null mice generally had no identifiable gastrointestinal abnormality, despite the fact that gastric PGE2 levels in null mice were only 1% of the levels observed in wild type mice (Langenbach et al., 1995).

The other two groups of mice were only treated with L435-3 or mock control.

Until recently, quantification of myocardial infarct size in mice was only possible by use of post-mortem histological analysis.

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