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First, the genetic background difference may lead to the phenotypic difference: whereas our Bmpr1a flox/flox and Pdx1-Cre mice have been bred on the C57BL/6 background for over 10 generations, the Pdx1-dnBmpr1a mice are generated on a mixture of C57BL/6 and CBA genetic backgrounds (Goulley et al., 2007).
A large number of genetically engineered mice are generated and studied as models for human prostate gland carcinoma studies.
A detailed explanation of how MST1 null mice are generated is described in a recent paper from our group [31].
These questions can only be further clarified when double, triple or even quadruple knockout mice are generated.
HIS mice are generated by engrafting immunodeficient mice with human hematopoietic stem cells (HSC) with or without human lymphoid tissues from fetal origin [10], [11], [12].
We found that the autoreactive T cells inducing autoimmune lesions in CCR7−/− mice are generated in the thymus where positively selected thymocytes including any autoreactive T cells are exported from the cortex.
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HDC−/− mice were generated according to previously described procedures [14].
Hdac6 tg chimera mice were generated (Fig. S2A and S2B).
The conditional CD146 knockout mice (CD146floxed/floxed mice) were generated in Model Animal Research Center of Nanjing University.
Hdac6 overexpression mice were generated from Hdac6 overexpression ES cells (Wang et al., 2015).
Time-activity curves for WT and Tg mice were generated (Fig. 3).
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