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STING deficient cells fail to produce type I interferons post cytoplasmic DNA stimulation (Ishikawa and Barber, 2008) and STING knockout mice are extremely susceptible to herpes simplex virus 1 infection (Ishikawa et al., 2009).
HLA-DR3 transgenic mice are extremely sensitive to TSS without the use of any sensitizing agents and faithfully recapitulate human TSS [19].
However, many standard phenotyping procedures for laboratory mice are extremely challenging to perform in wild-derived inbred strains [18], [22], and are likely to prove to be similarly difficult to carry out in wild-caught mice.
Considering that the endogenous TCR recombinations observed in non-Tg single RAG-deficient mice are extremely rare, the probability that a productive rearrangements occur in both α and β TCR loci and in the same cell is likely too low to result in receptor expression.
However, these mice are extremely obese without developing glucose intolerance (Ref. 46).
In models of mold infections, mice are extremely resistant to pulmonary challenge with spores.
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Regular chow fed homozygous Leptin145E/145E mice were extremely obese and infertile.
The onset and progression of SLE in female lpr mice is extremely consistent [28].
Because forelimb skeletal elements that formed in dcko mice were extremely small and misshapen, we examined endochondral growth and ossification on less severely affected hindlimb.
However, the authors reported that in other published experiments with P. berghei sporozoites the ID50 of sporozoites inoculated intravenously to CD-1 mice was extremely high (1,700 to 11,500) indicating that the sporozoite infectivity was extremely poor [9], [10].
The telomere length of laboratory inbred mice is extremely long (∼50 150 kb) [34], [35], whereas the length of zebrafish telomeres (∼4 20 kb) is much closer to that of human telomeres (∼8 10 kb) [23], [24], [36].
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