Reduced lean mass and increased myostatin target gene expression in mJNKKO mice are consistent with evidence demonstrating JNK is a negative regulator of myostatin activity (Fig. 5).
However, the increased synthesis and storage of insulin in the islets of the transgenic mice are consistent with either a direct regulatory effect of IAPP on the beta-cell or indirect stimulation of insulin production through IAPP-induced insulin resistance.
Fear-related behavioral changes in heterozygous and homozygous Atxn2 knockout mice are consistent with these observations in humans.
Thus, differences in the snRNP assembly activity of distinct tissues from normal mice are consistent with these studies.
Our data in FVB mice are consistent with the results by Martin et al, i.e. the high fat diet-fed FVB mice did develop diet-induced obesity.
Careful examination of the in situ images of fetal brain of uniparental disomic mice are consistent with our findings and suggest that there is maternal expression only [34].
Our findings of reduced disease associated with decreased neutrophilic chemoattractant levels in cis-UCA treated mice are consistent with the findings of Buanne et al [27].
Our results in Nrf2−/− mice are consistent with other studies demonstrating a hyper-inflammatory phenotype [29], including increased inflammatory responses and mortality after systemic LPS challenge [38], [39].
The abnormal behaviors specific to the maternal deletion mice are consistent with a brain-specific, maternal expression pattern for the Ube3a gene.
Our findings that USVs were reduced in M5 KO mice are consistent with an involvement of the M5 receptor in the activation of positive calls via the dopamine system.
Our results showing increased NOF center time in mGluR5 knockout mice are consistent with this and expand on a report demonstrating reduced anxiety-like behavior in these mice [34].
