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The mouse (or mice) are almost always the aggressors and, as in Tom and Jerry, are almost always the victors, killing Scratchy and any other cats around.
We found that, although the numbers of new neurons generated in the SGL of sdy−/− mice are almost equal to those of sdy+/+ mice, the rates of neuronal differentiation stemming from newly generated cells are significantly lower in sdy−/− mice.
A G protein-coupled receptor, endothelin receptor (ednr) b, is also expressed by neural crest-derived chromatophore precursors [37] [41] Homozygous ednrb mutant mice are almost completely devoid of melanocytes [4], [5].
While most of the immunologic defects that we observed in ezrin−/− mice are almost certainly a secondary consequence of defects in other organ systems, we noticed mild cortical thinning in both T cell conditional knockout mice and fetal liver chimeras (MHS, unpublished observations), suggesting that ezrin expression in thymocytes may play a small role in thymic development.
Parp-deficient mice are almost resistant to STZ-induced diabetes [ 48].
In this posture, both mice are almost immobile, looking in opposite directions and are not touching or seeing each other.
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Despite the exposure to hyperglycaemia for 17 weeks, glomerular size and ECM accumulation and configuration in the diabetic Ar-KO and BT mice were almost indistinguishable from those in the non-diabetic mice, characterised by improved glomerular hypertrophy, reduced cellularity and normalisation of mesangial expansion (Fig. 1a c).
Interestingly, our results follow a recent report that found that the rate of de novo somatic mutations in humans and mice is almost two orders of magnitude higher than the germline mutation rate and that both mutation rates are significantly higher in mice than humans [39].
As expected, gene regulation by WY14643 and fenofibrate in WT mice was almost completely abolished in PPARα −/− mice.
In addition, the strong anabolic effect of estrogen in young Runx2+/− mice was almost completely abolished in aged mice [20].
In the subcutaneous adipose tissue the funiculi of Nscl-2 mice were almost devoid of neurofilament (Fig. 1Aa d).
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