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The gene expression profiling analysis indicated that although skeletal muscle in adult Myog-deleted mice appeared morphologically identical to wild-type muscle, the muscle gene expression program was significantly modified.

Both heterozygous and homozygous mutant mice appeared morphologically normal and were fertile.

The macrophage population of Scnn1b-Tg mice appeared morphologically heterogeneous; some cells were abnormally large and many had a "foamy" cytoplasm as previously demonstrated [ 30, 32].

As shown in Figure 7c, although skeletal muscle from Ankrd2 KO mice appeared morphologically equal to WT muscle and no significant changes in fiber-type distribution were found, the slow gene expression program was significantly modified.

Dissociated CO of K5cre-CMVcaNrf2 mice appeared morphologically normal, but ultrasound treatment resulted in a faster destruction of CO from caNrf2-expressing mice compared to control animals (Fig 6G).

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In contrast, heterozygous mice appear morphologically normal [15].

It is possible that non-cholinergic neuron populations in Dlx-CKO mice appear morphologically normal but exhibit functional abnormalities.

The pancreas of both wild-type and Dicer1-hypomorphic mice developed normally and endocrine and exocrine cells appeared morphologically normal at E15.5 and P1 (Fig. 6A, B); the same abnormalities observed in adult Dicer1-hypomorphic mice were detectable at 4 weeks of ages (Fig. 6C), although the number of abnormal cells was less than that found in adult Dicer1-hypomorphic mice.

The axospinous and axodendritic synapses throughout the cerebellum appeared morphologically normal in wt and tg mice.

We therefore analyzed optic nerves of Cln3 -/- mice at 18 months of age by electron microscopy and immunohistochemistry against non-phosphorylated neurofilaments and detected axonal spheroids that appeared morphologically similar to those in younger Ppt1 -/- mice.

However, the intra-retinal vessels observed following epoetin delta treatment appeared morphologically dissimilar to RAP described for example in the retina of Vldlr-/ mice [40] The intra-retinal capillaries described in the current study were newly formed, reflected by their electron-lucent immature basement membranes and incomplete coverage of pericytes.

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