In the tissues samples stained with haematoxylin and eosin, the brain, heart, and kidney from 8to3737 nm GNP-treated mice appeared indistinguishable from tissues in control mice (data not shown).
The deletion was confirmed by Southern blot, PCR and northern blot analysis (Fig. 1C to E). PiT1Δ5/+ mice appeared indistinguishable from PiT1+/+ littermates, were viable and fertile producing offspring in normal Mendelian ratios when crossed with wild-type animals (Table 1).
In other respects, the rescued mice appeared indistinguishable from their wild-type littermates.
At birth, heterozygous (Atp6v0a4+/−, Het) and homozygous (Atp6v0a4−/−, KO) knockout mice appeared indistinguishable from their wildtype (Atp6v0a4+/+, WT) littermates and were born from heterozygous matings at Mendelian ratio.
Indeed, the SVZ regions of IDS-ko and wt mice appeared indistinguishable (Supplementary Figure 2), supporting the hypothesis that GAG metabolism has no significant influence on NSC self-renewal or early differentiation neither in vitro nor in vivo.
While heterozygous Pitx3WT/GFP mice appeared indistinguishable from wild-type animals at the behavioural and histological level (not shown), the Pitx3GFP/GFP knockouts displayed a phenotype which is very similar, if not identical, to the previously described aphakia mice (Nunes et al., 2003; Smidt et al., 2004).
Brn3a +/− and Brn3a +/+ mice appear to be indistinguishable in appearance and overall health and individual Brn3a +/− DRG neuronal cell bodies do not differ in appearance or number relative to Brn3a +/+ controls (Xiang et al., 1996).
To a visitor, Darfurians appear indistinguishable.
Spain and France appear indistinguishable.What could be behind the risk index's failure?
Yet they appear indistinguishable from the aggressive variety under the microscope.
