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In separate letters sent to Nature Methods, scientists from Intellia Therapeutics and Editas Medicine criticized a report in the journal that claimed the gene-editing tool CRISPR had caused unexpected mutations in the genomes of mice and which cast a shadow over efforts to initiate human studies using the technique.
Our transgenic mice resemble to some extent moderately overexpressing caspase-8 transgenic mice [34], whose survival rates do not significantly differ from wild type mice and which developed a dilated heart and decreased systolic function.
acnes overgrowth, which only affects humans, but not mice, and which triggers a severe inflammatory response (Makrantonaki et al, 2011).
We therefore sought to determine which cells within the tumour might be responsible for the reduced metastasis in DMOG-treated mice and which PHD enzyme was critical.
However, whether netrin-1 receptors are expressed in the retinas of OIR mice, and which subtypes are involved in retinal neovascularization during this expression, are presently unknown.
We have made reference to perirhinal cortex lesions, which yield a false recognition effect identical to that seen in the tgCRND8 mice, and which can also be rescued by sensory restriction (McTighe et al., 2010).
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The team will take part in a $65.4 million effort to catalog the cell types in the brains of mice and determine which genes each type uses.
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