Given that there were no major differences between the TTC9A+/+ and TTC9A−/− male mice, and we argue that TTC9A−/− induced anxiogenic behavior is specific to female mice.
We have also found that the peptide can target tumors when injected into mice, and we are pursuing this exciting finding with imaging and therapy in mind.
Here we utilize miniaturized plasma exchange to deliver labeled albumin to tissues in live mice, and we demonstrate that breakdown of albumin contributes to the supply of free amino acids in pancreatic tumors.
We observed upregulation of IL-4 transcription by MCp in mLN and spleens of helminth-infected 4get mice, and we demonstrated by intracellular cytokine staining production of IL-4 and IL-6 by the mLN MCp in helminth-infected mice.
"All three of us were in this really small apartment, and there were roaches, and there were mice, and we lived above this bar.
A pacing chamber was designed for use with mice and we compared the sexual behavior of female mice that were tested in both pacing and nonpacing paradigms and under different hormone conditions.
We validated Nampt's involvement in arthritis using a CIA mouse model7,8 in wild-type and Nampt heterozygous knockdown DBA/1J mice, and we investigated further the pathways underlying Nampt's mechanism in arthritis through loss-of-function and gain-of-function studies experiments in mouse bone marrow-derived macrophages (BMM) and RNA sequencing (RNA-seq) of CIA mouse tissue.
Overall, in this study, we provide critical new insights into the understanding of the natural history of metastatic disease in mice and we demonstrate that early in cancer evolution macrophages and early DCCs appear to play a seminal role in metastatic breast cancer that can manifest later in life of these mice.
These T cell hybridomas have been used to produce transgenic mice, and we are currently analyzing these transgenic mice as well as their T cell receptors, which recognize GAD65 peptides bound by I-Ag7, to understand how this MHC class II molecule presents peptides in such a way as to induce an inflammatory response resulting in the destruction of the islets.
We observed mitochondrial fragmentation in CCP1 null cells and in neurons from pcd mice, and we documented reduced mitochondrial fusion in cells lacking CCP1.
"Arguably the species we know the best from a biological and cellular perspective is mice and we thought it was a great place to start with a cultured product as cats naturally eat mice, except in this case, no mouse has to suffer," says Bethencourt.
