Moreover, this maneuver resulted in complete absence of anti-mouse F9 and sustained expression of functional mouse F9 in some hemophilia B mice, particularly in those animals treated with the immunosuppressive drug cyclophosphamide.
It should also be noted that the MoPn agent is a natural pathogen for the mouse and sustains a significantly more vigorous infection, a far higher incidence of ascending upper genital tract infection, and higher acute inflammatory responses than human C. trachomatis serovars in the mouse [ 3].
In C57BL/6 mice, this staining was still evident at 2 weeks, with less staining evident by 6 weeks, in line with the view that proteoglycan loss is due to increased cartilage destruction; u-PA-/ mice showed increased and sustained DIPEN staining compared with C57BL/6 mice, once again in line with continuing proteoglycan destruction.
Moreover, chronic systemic administration of recombinant IL-12 in BALB-neuT mice induced high and sustained IFN- γ production, as detected in the sera of treated mice that in turn caused a delay in tumor onset and a reduction in the number of mammary glands affected by the tumor [ 109, 110].
In response to oral exposure to TCDD, sensor mice exhibited dramatic and sustained activation of AhR.
Collectively, these data suggest that IL-10−/− mice show significant and sustained Mtb control, which correlated with an accelerated and enhanced expansion of CD4+ T cells in the dLN, together with increased differentiation, expansion and migration of Th1 cells to infected lungs (Fig. 2B).
A high IL-12 content was early detected in the organs of immunized mice and was sustained at least for 4 days in the spleen and liver, and 8 days in the lung.
u-PA-/ mice also showed increased and sustained bone erosion compared with C57BL/6 mice.
All seven mice treated with SGN-75 showed a delay in tumour growth, whereas two of seven mice showed a complete and sustained regression.
