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WT controls always belong to the same litter than transgenic mice and received the same treatment.
After the tumour diameter reached about 5 mm, the mice bearing K562 cells were randomly assigned to four groups, each containing six mice, and received various regimens every other day for 14 days.
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In the dose response study in mice, C57BL/6 mice were anesthetized and received 1 h MCAo by intraluminal suture.
A total of 42 male R6/2 mice (22 R6/2 mice received oral B401 treatment and 20 R6/2 mice received sham treatment) were observed in this study.
P8-14 mice were anesthetized and received analgesia.
Treatment groups (mice and hamsters) received 90 mg/kg of chloroquine alone (intraperitoneally).
To obtain a sufficient number of "complete responders" for statistical analysis, the experiment was repeated in experiment 2 with 2 control mice, 4 mice receiving free AuNRs, and 4 mice receiving NSC.AuNRs.
All mice were singly housed and received water AL.
In fact, there were no differences in body weight between the EPO transfected high-fat fed mice and mice receiving normal chow (P = 0.23, n = 8).
We focused on synovial thickening/activation, cartilage damage and enthesophyte/osteophyte formation in both LDLr−/− mice and mice receiving a cholesterol-rich diet.
GDF11 was clearly shown to have rejuvenating effects in heterochronic parabioitic models (where blood is shared between a young mouse and older mouse), and in mice that received GDF11 alone.
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