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S.A.N. generated the floxed TNF mice and provided intellectual expertise.
M.E.X., E.A., R.D., M.A.-R., M.M.M. and D.W.L. supplied HFD-fed mice and provided experimental support.
CellMAC-encapsulated EPO-production cell lines induced increased EPO serum levels when implanted intraperitoneally into mice and provided robust glycoprotein production during standard stirred-tank bioreactor operation.
Compared to the parental wild-type SEZ, the ΔhasB mutant was highly attenuated in mice and provided 100% protection against lethal challenge when administered as a live vaccine.
Our results indicate that transient depletion of B cells with an anti-CD20 antibody had no substantial effect on the anti-capsid antibody response in mice and provided no additional benefit to SVP[Rapa] treatment (Supplementary Fig. 8).
Racemic MDMA (0.3 30 mg/kg), S-MDMA (0.3 30 mg/kg), R-MDMA (0.3 50 mg/kg) and saline vehicle (10 ml/kg) were comprehensively evaluated in fully automated and computer-integrated activity chambers, which were designed for mice, and provided a detailed analysis of the frequency, location, and/or duration of 18 different activities.
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Whether dirty mouse models represent the human condition better than standard lab mice — and provide a better testing ground for drugs — also remains to be seen.
We thank J. Lewis, K. Duff, D. Westaway and D. Borchelt for generating these lines of transgenic mice and providing access to them.
The purpose of the study was to test whether C5a peptidase encapsulated within a biodegradable polymer can act as a vaccine and elicit an immune response to prevent group B streptococci (GBS) infection in mice and provide protection to pups.
This engineering process is known to create humanized mice, and provide opportunities to study hepatitis C within the 3D architectural design of the liver and evaluating antiviral compounds.
The results may shed light on the history of domestication of mice, and provide a starting point for further analysis of the genetic basis of tameness in mice.
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