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These results suggest that DBA mice, and particularly DBA males, exhibit resistance to the elevated expression of leukocyte-associated transcripts with HF diet that is characteristic of other mouse strains included in our analysis.
Next, we investigate the underlying molecular mechanisms mediating enhanced anti-tumor immune reactivity in Nr2f6−/− mice and particularly increased cytokine production in Nr2f6−/− CD4+ T cells in vitro.
Some variability was found in the intensity of vacuolation dependent on the vCJD isolate, most notably in the VM mice and particularly in the superior colliculus, hypothalamus, and thalamic regions.
Cellular models for AD as well as transgenic mice, and particularly triple transgenic models that combine both pathologies, are valuable tools in monitoring therapeutic interventions at the mitochondrial level.
The use of genetically modified mice, and particularly the advent of tissue-specific gene deletion, has revealed a number of factors that either promote, or delay, involution and apoptosis.
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TLR8 deficient mice (B6.TLR8−/−) and particularly double TLR8/9-deficient mice (B6.TLR8/9−/−) displayed marked induction of TLR7, which was associated with more severe disease.
By contrast, it was highly intense in onset and postsymptomatic G1H+/− mice, and was particularly prominent in glial cells, but was undetectable in neurons.
Since grey mouse lemurs, and particularly those under winter phenotype, tend to overfeed when isolated and thus gain mass during the ad-libitum period, energy intake was clamped to the level required to stabilize their body mass.
Compared to wild type, the total oxygen consumption and the respiratory exchange rates (RER) in PDZ-RhoGEF KO mice were higher and particularly increased at time points towards the end of the light cycle (revised Figure 2A,B, Figure 2 figure supplement 2A C).
Based on the stringent conservation between mouse and human, particularly in the alternatively spliced regions (Fig. 6C D), it is possible that this human CPEB3 protein isoform has an N terminal truncation of 216- aa instead of 317-aa.
However, translating results to human conditions requires a good understanding of similarities and, more importantly, differences between the human and mouse complement system and particularly regulation.
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