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These data correlate with the attenuated behavioral light responses observed in these mice and indicate a direct influence of the SHARP proteins on circadian gene regulation in the SCN.
In particular, the dramatic decrease in 5-HT content observed in hippocampus, hypothalamus and frontal cortex could well account for the behavioral despair and aggressiveness displayed by the Gpr3−/− mice and indicate a role for GPR3 in modulating the serotonergic system.
These elevations in plasma PTH were accompanied by a 0.25 0.30 mmol/L increase in plasma calcium values in wild-type, Nuf/+, and Nuf/Nuf mice and indicate that gene dosage did not impact on drug efficacy.
The peripheral parasitemia, and luciferase activity (p/s) in the whole body, 8 days post infection, are presented here for 2 representative mice and indicate the discrepancy between these two values.
Our results provide the first quantitative description of the genetic architecture of haloperidol response in mice and indicate that additive, dominance-like inbreeding and parent-of-origin effects contribute strongly to treatment effect heterogeneity for this drug.
Collectively, these results show that BMPER mRNA expression is increased by cultivation in high glucose-containing media and in diabetic mice, and indicate the involvement of BMPER in high glucose-increased ALP activity in HCASMCs.
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This intervention significantly improved healing rates of chronic TMP in plg /– mice and indicates an important role of plasminogen in TMP healing.
In the late 1980's, Kappler demonstrated central tolerance in mice and indicated that tolerance induction may occur in the thymus [19].
This effect was also observed at the lowest dose (1 mg/liter) in female mice and indicates the potential sensitivity of this endpoint for evaluating the microbiological risk of tetracycline residues.
Patients with mutations in the αA-crystallin gene develop similar microcornea and corneal opacities [48], [49], substantiating our findings in knock-in mice and indicating that αB-crystallin also plays a critical role in the maintenance of corneal clarity.
Early studies demonstrated enhanced regeneration of hepatocyte proliferation following administration of 5-HT to PHx mice and indicated a requirement for 5-HT1A/1B and 5-HT2B receptors, although these early studies suffered from limited availability of receptor-specific agonists and antagonists.
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