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Our results for the first time demonstrate that p53 deregulation participates in abnormal axonal development in npc1−/− mice, and identify the signaling pathway involved in this process.
Here, we investigate the reduced thymus and spleen size in Lmna-/ mice and identify a progressive, age-dependent impairment in T and B cell development.
Here we characterize alterations in the biomechanical responses of bones from PPARβ−/− mice and identify new molecular targets, namely PPARγ and myostatin, that may contribute to the impairment of the muscle and bone functions in diabetes.
We demonstrate that endurance exercise attenuates age-associated changes to skin in humans and mice and identify exercise-induced IL-15 as a novel regulator of mitochondrial function in aging skin.
These studies represent the first attempt to recapitulate the complex clinical parameters of neoadjuvant therapy in mice and identify a novel tool to compare systemic antiangiogenic treatment effects on localized and disseminated disease.
The study documents that Ltbp-4L and Ltbp-4S have distinct roles in elastic fiber formation and postnatal survival in mice and identify fibulin-4 as an interaction partner of both Ltbp-4 isoforms.
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The researchers transplanted the fractions into mice, and identified which fractions caused leukaemia and which did not.
Volcano plot analysis confirmed upregulation of Arg2 gene expression in db/db AAV8-Arg2 mice, and identified the hepatocyte regulator of G-protein signaling 16 (RGS16) as among the most highly suppressed genes in db/db AAV8-Arg2 mice (Fig. 8d).
We administered chlorpyrifos (CPF), a model organophosphate pesticide to pregnant mice and identified visuospatial deficits in adult offspring using performance in the Morris maze.
A team of researchers led by Hopi Hoekstra, professor of organismic and evolutionary biology and molecular and cellular biology, studied two species of mice — oldfield mice and deer mice — and identified four regions in their genome that appear to influence the way they dig burrows.
As described in a Jan . 16paper in Nature, a team of researchers led by Hopi Hoekstra, professor of organismic and evolutionary biology and molecular and cellular biology, studied two species of mice – oldfield mice and deer mice – and identified four regions in their genome that appear to influence the way they dig burrows.
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