Sentence examples for mice and do from inspiring English sources

Similarly, DBA/2J mice have a spontaneously arising mutation in the Klrd1 gene that prevents expression of CD94, yet NK cells develop normally in these mice and do not cause overt autoimmunity [24].

RAW 264.7 cells are derived from BALB/c mice which express LTS Nlrp1b, whereas IC-21 macrophage-like cells are derived from LT-resistant (LTR) Nlrp1b expressing C57BL/6 mice and do not undergo pyroptotic death in response to LT. IC-21 cells showed no increase in LR/HG population in response to LT (Figure S2A).

In our model, where antigen encounter is likely to occur in the absence of overt inflammation (in the absence of help, Clone 4 cells are still tolerized in irradiated mice and do not differentiate into effectors [29]), IL-2 appears to be the major factor driving help-dependent differentiation of memory-like CD8+ T cells into effectors in response to self-antigen cross-presentation.

What are the targets that are responsible for the phenotype in the miR-1-1 knockout mice and do they overlap with the targets that the authors previously identified to be responsible for the miR-1-2 knockout phenotype?

- Also, multiple murine studies have observed that survival of the peripheral T cell compartment is dramatically reduced in the absence of autophagy., In contrast to mature T cells, mature peripheral B cells do not require autophagy for survival, as demonstrated in Atg5 −/− mice, and do not have detectable levels of basal autophagy.

The authors observed that diabetes-prone non-obese diabetic (NOD) mice are lymphopenic and have reduced numbers of T cells compared to non-autoimmune strains, such as wild type BALB/c mice, NOD MHC-matched B10 mice and congeneic B6.Idd3.NOD mice that contain a 0.35 centimorgan protective interval from B6 mice and do not develop diabetes.

Such homeostatic maturation occurs continuously in germ-free mice and does not require TLR signals (Wilson et al., 2008).

Ces1d protein abundance did not increase by clofibrate administration to wild-type C57BL/6 mice and did not decrease in PPARα deficient mice (Dolinsky et al., 2003).

At baseline, Nlrp3 KO were indistinguishable from WT mice and did not differ in body, liver, spleen, or skeletal muscle weights normalized to tibia length (Additional file 3A C).

It was found that compound 12 resulted in 97.4% reduction in fungal load in mice and did not show any profound proliferative effect at lower dose (0.001 mg/ml).

oAC protects against ECM in mice, and does not interfere with the pharmacokinetics of parenteral artesunate.