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Because of the lack of a traceable tumor Ag-specific T cell response in both MCA-induced tumor models and in p53+/− mice, and development of different and unpredictable tumor types in the latter, it is difficult to correlate the presence or lack of iNKT with tumor-specific a CTL response and its involvement in cancer immune surveillance.
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Alternatively human cancer cells can be injected into mice and tumor development monitored in xenotransplants.
Stationary-phase promastigotes (2 × 10) were injected into the footpad of BALB/c mice and lesion development monitored.
In vivo, U87.Mxi1.14 cells were not tumorigenic in nude mice and delayed development of tumours was observed with U87.Mxi1.22 cells.
In addition, disruption of H-Ras and N-Ras, individually or in combination, reveals dispensability of both loci for mouse growth and development [7].
To assess ADHFE1 expression during mouse gut differentiation and development, six pregnant female mice (Orient Bio Inc., Seongnam, Korea).
In particular, mouse and human development differs during organogenesis such as tail and sensory organ development.
During development, occludin phosphorylation seems to be regulated in a stage-specific manner as shown during early mouse and Xenopus development [ 29, 58].
In the present study, we developed Slitrk6-knockout mice and analyzed the development of their auditory and vestibular sensory organs.
For example TGF-β induces development of both Treg and Th17 in mice and suppresses Treg development in humans [ 97].
The MYC proto-oncogene is an essential gene whose function is required for normal mouse and fly development [1] [3].
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