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As shown in Table 1, cGMP levels in homozygous mice were significantly elevated compared with wild-type littermates, with heterozygous mice also showing elevated levels that fall just short of statistical significance.
In contrast, after the second immunization antigen-specific IgM was detected, which steadily increased after the third immunization with approximately 25 40% of responder mice also showing an antigen-specific IgG response (Figure 2A).
Although DOI administration produced head twitches and body jerks in all subjects, the SJL and C57 mice spent a longer time performing body jerks than the ABH and CD1 mouse strains, with the C57 mice also showing increased elevated levels of spontaneous locomotion and increased perseveration on the set-shifting task.
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The mice also showed completely normal responses to touch-induced pain.
These mice also showed improved learning and memory performance.
4T1 tumor-bearing mice also showed a higher survival rate than free UA and free HCPT.
TERC KO mice also showed increased cellular apoptosis and impaired spatial learning.
The Cbfa1-deficient mice also show an abnormality in cartilage development.
PRGF-Endoret-treated APP/PS1 mice also showed decreased astrocyte reactivity, and prevented protein synaptic loss.
In females, the 5XFAD mice also showed 12% less total sleep than WT (p < 0.01).
In addition, the knockout mice also showed lower levels of inflammation.
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