All the various morphological Otx2- and PV-IR cell types in the control mice were also identified in the KO mouse SC.
Prior to development of T-ALL in our TLX1 mice, we also identified a partial block in T-cell differentiation.
Gene expression profiling of Prl-/ mice has also identified unique targets of mammary development.
Characterization of JAM-C-knockout (KO) mice has also identified additional functions for JAM-C, such as roles in cell polarity, immunity, and inflammation (10, 19, 23).
Comparative MS analyses from Prmt4+/+ and Prmt4−/− MEFs found that all but one of the identified PTMs were conserved in mouse, but also identified additional modifications resulting in a total of 22 PTMs (Supplementary Table S1 at http://www.BiochemJ.org/bj/441/bj4410803add.htm).htm
In the Salmonella experiments, bacterial numbers were as much as 20,000-fold lower in the vaccinated mice and scientists also identified antibodies specific to the siderophores that seem responsible for the protection.
While PirB is specifically a mouse protein, Kim also identified for the first time an analogous beta-amyloid receptor in the human brain: a protein called LilrB2.
Proteins homologous to hypothetical human proteins and mouse cDNAs were also identified.
The SMA mouse model study also identified enrichment of ECM biology in the cohort of aberrantly spliced genes, although quantitative analysis was not presented and the finding was not emphasized.
However, by comparing the copy number landscape between mouse groups, we also identified CNAs that were present in multiple models (Fig. 2; Supplemental Table 4), which can be considered as common CNAs of murine mammary oncogenesis.
