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GF and GFC mice also failed to show normal preference for social novelty displayed by CC mice during trial 3, as seen in the automated tracking images (d), the time spent in each chamber (e) and the difference between time spent in the chambers containing a novel and familiar mouse (f).
Another study using rd mice also failed to report a significant light aversion response following exposure to illumination of 2800 Lux [20].
These newborn mice also failed to mount effective adaptive immune response and the immune infiltrate predominantly consisted of macrophages with activated resident microglia (Fig. S4).
This conclusion was not limited to C57BL/6J mice, as we found that DBA/2J mice also failed to show altered responding following reinforcer devaluation (again, despite clear evidence of the formation of a successful food-sickness pairing).
In addition, TLR2-deficient mice also failed to develop AAA.
GluN1hypo mice also failed to acquire a simple, non-spatial visual discrimination task.
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D1 knockout mice also fail to self-administer cocaine [28], suggesting that the reinforcing effects of OSS may be mediated by neural substrates more similar to psychostimulants than to food.
Aged mice also fail to mobilize intracellular fuel reserves from brown adipocytes and exhibit deficiency in homeothermy.
DBH knockout mice also fail to show increased anxiety following acute cocaine administration, as indexed in the elevated plus maze [ 283].
Adult female mice also fail to adopt a characteristic mating stance when exposed to male suitors, and are unable to detect and remember male-specific non-volatile individuality cues [ 5].
Nevertheless, the relative importance of these impairments is called into question by experimental evidence from our laboratory, which demonstrates that aged immunoglobulin transgenic mice also fail to generate new B cells efficiently [ 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com