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Furthermore, IFNγ and iNOS deficient mice also did not show signs of disseminated disease (Figure 1B).
Sera from these mice also did not produce antibody to cp-MVP vaults by Western blot analysis (data not shown).
Pten-deficient mice also did not develop bladder tumours at all the available timepoints (up to day 700).
Spleens and livers from immunized and subsequently challenged mice also did not contain any viable F. tularensis.
Mast cell-deficient sash mice also did not develop colitis following piroxicam exposure, either with or without reconstitution with WT BMMC (Figure 2).
The P2+P7 PCP mice also did not display performance deficits on any of the measures within the sensorimotor battery or in terms of ASR/PPI responsivity.
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These mice also do not have intact immune systems: Humans might develop antibodies to the monoclonals, rendering them ineffective.
We have previously reported that N2KO mice also do not reduce circulating leptin levels following 24-hour exposure to cold [29].
Arthropathic Tax transgenic mice also do not have an increased level of serum IL-17A or proportion of splenic Th17 cells (Figure S1).
TRAIL-knockout mice also do not induce thymocyte apoptosis, which is deregulated in autoimmune diseases.
Allergic mice also do not exhibit spontaneous AHR, and smooth muscle hyperplasia is not easily demonstrated [ 8].
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