These mice also develop PDC-E2 antibodies, which precedes the development of liver abnormalities and ANA [49].
In extreme cases, apoE4 mice also develop marked choroidal neovascularization, a hallmark of exudative AMD.
Inactivation of the Sirt7 gene in mice results in lifespan reduction and the mutant mice also develop cardiac hypertrophy and inflammatory cardiomyopathy (Vakhrusheva et al. 2008a, b).
Now, a new study in the January issue of Infection and Immunity shows that the treated mice also develop allergies to another substance, egg white protein.
Kcnq1−/− mice also develop metaplasia, dysplasia and pre-malignant adenomatous hyperplasia of the stomach independent of infection [11].
Importantly JNK1−/− mice also develop spontaneous intestinal tumours, indicating that JNK1 functions as a tumour suppressor for this tissue type [20].
Consistent with this small fiber neuropathy, Fabry mice also develop a demonstrable deficit in their ability to respond to a heat stimulus [22], [23].
However, Ets1 BT mice also develop deep down-growths of the epidermis into the dermal compartment, which have not been reported in these other strains.
The results of our study show that the R120G mutation causes cataracts at a young age, and some mice also develop corneal opacity and small eye/lens phenotypes.
Commensurate with the pathology, the physical symptoms of the mdx mouse tend to be relatively mild, with muscle weakness more obvious after exercise or lengthening contractions.[4] [6] Mdx mice also develop decreased cardiac systolic function slowly over time.
At about 12 m.o.a., 3xTg-AD mice also develop extensive neurofibrillary tangles, first in the hippocampus (in particular within pyramidal neurons of the CA1 subfield) and then in the cortex [11].
